An Approach to Linezolid and Vancomycin against Methicillin Resistant Staphylococcus Aureus
نویسنده
چکیده
In vitro activities of linezolid and vancomycin which were evaluated against methicill in resistant Staphylococcus aureus (MRSA). One hundred clinical isolates of MRSA were collected. The minimum inhibitory concentrations (MICs) of linezolid and vancomycin were determined by the Epsilon-test method. The results showed 100 percent susceptibility of linezolid and vancomycin against MRSA isolates. According to the MIC90 values, linezolid was the most active agent. The heterogeneity of methicillin resistance determined by the dropped plate count revealed homogeneous resistance to methicillin of all isolates.
منابع مشابه
In vitro activity of linezolid alone and in combination with glycopeptides against methicillin-resistant Staphylococcus aureus
The emerging resistance to antibiotics and the poor pipeline of new antibacterials is creating a major health issue worldwide. Combinations of two antibiotics or antibiotics with adjuvant are emerging as a promising therapeutic approach. Staphylococcus aureus represents a major threat to a broad range of healthcare and community associated infections. It is imperative to develop novel antimicro...
متن کاملIn vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci.
We examined the activity of CB-181963, a novel cephalosporin, against methicillin-resistant Staphylococcus aureus (MRSA) (n = 200), methicillin-susceptible S. aureus (MSSA) (n = 50), glycopeptide-intermediate Staphylococcus species (GISS) (n = 47), and VRSA (n = 2) isolates. CB-181963 exhibited MIC profiles similar to those of linezolid against MRSA and GISS; however, activity against MSSA was ...
متن کاملComparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium.
Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log(10) killing at 24 h, and rates of killing agains...
متن کامل[In vitro activity of linezolid against clinical isolates of methicillin-resistant Staphylococcus aureus].
In recent years, there has been a dramatic increase in the number of infections caused by multidrug-resistant Gram-positive microorganisms, making necessary the search for alternative antibacterial agents. Linezolid is a new synthetic antimicrobial agent with activity against multidrug-resistant Gram-positive cocci. The objective of this study was to determine the in vitro activity of linezolid...
متن کاملComparison of in vitro efficacy of linezolid and vancomycin by determining their minimum inhibitory concentrations against methicillin resistant Staphylococcus aureus (MRSA).
OBJECTIVES To compare the in vitro activities of vancomycin and linezolid against methicillin resistant Staphyloccus aureus in our set up to help in formulating a better empirical treatment and reduce the emergence of vancomycin resistant Staphylococcus aureus. METHODS The study was conducted over a period of 6 months (1st July 2009-31st Dec 2009). Fifty Methicillin resistant Staphylococcus a...
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